Understanding Arthritis

The more you know about arthritis, the more you can do to try to manage it. Explore some of the facts about joint pain and learn what you can do to help relieve it.

 

Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis in the U.S. Approximately 27 million adults have reported being diagnosed with OA by their doctor. While the cause of OA is unknown, it occurs when cartilage in joints breaks down over time.

Quick Facts About OA

  • One in 2 people in the U.S. will experience some form of OA in their lifetime.
  • OA is much more common in women than men.
  • OA accounts for more than 50% of arthritis cases in the U.S. (nearly 27 million of the 46 million adults who have reported doctor-diagnosed arthritis).

Symptoms of OA

The most noticeable symptom of OA is a feeling of pain in or around the joint. Other symptoms include:

  • Tenderness and stiffness in the joint
  • Loss of flexibility or range of motion
  • Grating sensation or sound in the joint, also known as crepitus

Osteoarthritis Illustration

Normally, the ends of the bones in a joint are cushioned by cartilage. In this example of a knee with osteoarthritis, a joint commonly affected by OA, the cartilage thins out, and the ends of the bones become exposed to each other and rub together. This can damage the bones, with pain and decreased range of motion in the knee. Bone spurs, or bony projections, can also develop along the joint, which can also cause pain when extending or bending the knee.

 

Rheumatoid Arthritis

Unlike osteoarthritis, rheumatoid arthritis (RA) is an autoimmune disease. An autoimmune disease is when the body’s defense system malfunctions and begins to mistakenly attack itself.

Quick Facts About RA

  • Typically, RA affects the smaller joints first, such as the ones in your hands and feet, and then may move on to other joints.
  • RA is 2 to 3 times more common in women than in men and can start developing as early as age 20.
  • In addition to symptoms of swelling and pain, RA can cause fever, fatigue, and loss of appetite, which can lead to weight loss.

Symptoms of RA

Like OA, the primary symptom of RA is pain felt in and around the joints. In addition to pain, other symptoms of RA found in joints may include:

  • Swelling of joints
  • Joints that are tender to the touch
  • Red and puffy joints
  • Morning joint stiffness that lasts at least 30 minutes but can continue for hours

Rheumatoid Arthritis Illustration

In this example of a knee with rheumatoid arthritis, there is swelling and thickening of the synovial membrane, the connective tissue that lines the joint cavity and produces fluid to lubricate the joint. There is also loss of the cartilage and bone. All of this can result in pain.

 

Scroll for Important Safety Information and Indications.

IMPORTANT SAFETY INFORMATION

All prescription NSAIDs, like CELEBREX, ibuprofen, naproxen, and meloxicam have the same cardiovascular warning. They may all increase the chance of heart attack or stroke that can lead to death. This chance increases if you have heart disease or risk factors for it, such as high blood pressure or when NSAIDs are taken for long periods.

CELEBREX should not be used right before or after certain heart surgeries.

Serious skin reactions, or stomach and intestine problems such as bleeding and ulcers, can occur without warning and may cause death. Patients taking aspirin and the elderly are at increased risk for stomach bleeding and ulcers.

Tell your doctor if you have:

  • A history of ulcers or bleeding in the stomach or intestines
  • High blood pressure or heart failure
  • Kidney or liver problems

CELEBREX should not be taken in late pregnancy.

Do not take CELEBREX if you have bleeding in the stomach or intestine, or you've had an asthma attack, hives, or other allergic reactions to aspirin, any other NSAID medicine or certain drugs called sulfonamides.

Life threatening allergic reactions can occur with CELEBREX. Get help right away if you've had swelling of the face or throat or trouble breathing.

Prescription CELEBREX should be used exactly as prescribed at the lowest dose possible and for the shortest time needed.

INDICATIONS

CELEBREX is indicated for the relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, and for the management of acute pain in adults.

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