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How CELEBREX Works

The human body contains many enzymes that facilitate chemical reactions in the body. One of these enzymes is Cyclooxygenase-2 (COX-2), which is involved in causing inflammation and pain in parts of the body where there is arthritis or injury.

CELEBREX at recommended doses selectively inhibits COX-2, which helps relieve arthritis pain and inflammation as well as acute pain in adults.

Safety and CELEBREX

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arrowUnderstanding Osteoarthritis

kneegraphic

For illustrative purposes only.

Rheumatoid arthritis can be felt in and around any of the joints in your body. In this example, white blood cells attack the joint, which results in swelling of the connective tissue that lubricates the cavities of joints — the synovial membrane. This swelling releases proteins that thicken the joint and causes pain. These proteins can also erode the cartilage and bones in the joint as well as the ligaments that surround it.

Scroll for Important Safety Information and Indications.

IMPORTANT SAFETY INFORMATION

All prescription NSAIDs, like CELEBREX, ibuprofen, naproxen, and meloxicam have the same cardiovascular warning. They may all increase the chance of heart attack or stroke that can lead to death. This chance increases if you have heart disease or risk factors for it, such as high blood pressure or when NSAIDs are taken for long periods.

CELEBREX should not be used right before or after certain heart surgeries.

Serious skin reactions, or stomach and intestine problems such as bleeding and ulcers, can occur without warning and may cause death. Patients taking aspirin and the elderly are at increased risk for stomach bleeding and ulcers.

Tell your doctor if you have:

  • A history of ulcers or bleeding in the stomach or intestines
  • High blood pressure or heart failure
  • Kidney or liver problems

CELEBREX should not be taken in late pregnancy.

Do not take CELEBREX if you have bleeding in the stomach or intestine, or you've had an asthma attack, hives, or other allergic reactions to aspirin, any other NSAID medicine or certain drugs called sulfonamides.

Life threatening allergic reactions can occur with CELEBREX. Get help right away if you've had swelling of the face or throat or trouble breathing.

Prescription CELEBREX should be used exactly as prescribed at the lowest dose possible and for the shortest time needed.

INDICATIONS

CELEBREX is indicated for the relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, and for the management of acute pain in adults.

For more information about CELEBREX and other NSAIDs, please see the Medication Guide.

For further information on CELEBREX, please see the full Prescribing Information.

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Scroll for Important Safety Information and Indications.

IMPORTANT SAFETY INFORMATION

All prescription NSAIDs, like CELEBREX, ibuprofen, naproxen, and meloxicam have the same cardiovascular warning. They may all increase the chance of heart attack or stroke that can lead to death. This chance increases if you have heart disease or risk factors for it, such as high blood pressure or when NSAIDs are taken for long periods.

CELEBREX should not be used right before or after certain heart surgeries.

Serious skin reactions, or stomach and intestine problems such as bleeding and ulcers, can occur without warning and may cause death. Patients taking aspirin and the elderly are at increased risk for stomach bleeding and ulcers.

Tell your doctor if you have:

  • A history of ulcers or bleeding in the stomach or intestines
  • High blood pressure or heart failure
  • Kidney or liver problems

CELEBREX should not be taken in late pregnancy.

Do not take CELEBREX if you have bleeding in the stomach or intestine, or you've had an asthma attack, hives, or other allergic reactions to aspirin, any other NSAID medicine or certain drugs called sulfonamides.

Life threatening allergic reactions can occur with CELEBREX. Get help right away if you've had swelling of the face or throat or trouble breathing.

Prescription CELEBREX should be used exactly as prescribed at the lowest dose possible and for the shortest time needed.

INDICATIONS

CELEBREX is indicated for the relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, and for the management of acute pain in adults.

For more information about CELEBREX and other NSAIDs, please see the Medication Guide.

For further information on CELEBREX, please see the full Prescribing Information.